At 72 weeks, tirzepatide 15 mg (SURMOUNT-1, Jastreboff et al., NEJM 2022) delivered -20.9%
While everyone is talking about silencing food noise and feeling full, few realize they already possess the necessary equipment
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Diet-induced obesity (DIO) mice were generated by starting a high-fat diet (HFD-60, lipid 60 kcal%, Oriental Yeast) feeding for C57B6J (B6) mice (Oriental Yeast) at six weeks of age
More recently, their anti-inflammatory, cardioprotective, and neuroprotective properties have been explored in conditions such as cardiovascular disease (24), non-alcoholic fatty liver disease (25), osteoarthritis (26), rheumatoid arthritis (27), Alzheimers (28), and Parkinsons disease (29)
The manufacturer recommends that patients using oral hormonal contraceptives switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after tirzepatide initiation and for 4 weeks after each dose escalation