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by the use of online-clean-up-techniques

Also, the stereochemistry change of penetratin from L- to D-form showed differential effects according to the cargos because IFN- with D-penetratin showed elevated intestinal and nasal mucosal absorption compared to that of L-penetratin but this phenomenon was not observed in the cases of exendin-4 and glucagon-like peptide 1(GLP-1) delivery in rats (Khafagy et al., 2009b)