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4 Metabolic interactions in the hepatocellular carcinoma tumor microenvironment 4.1 Metabolic crosstalk between hepatic stellate cells and hepatocellular carcinoma cells Cancer cells maintain an alkaline intracellular environment by undergoing aerobic glycolysis, which generates a large amount of protons that are transported to the extracellular space through upregulation of H+ transport proteins

GSH-deficient cells showed increased Dnmt activity and decreased Tet hydroxylase activity (Fig

323 Interfering with drug-resistant molecules through genetic modification is a common therapeutic strategy

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