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When HbA1c is considered unreliable for example, due to B12 deficiency or anaemia UK and WHO guidance recommends using a fasting plasma glucose test or a 75 g oral glucose tolerance test (OGTT) for diabetes diagnosis or assessment

If there is a deficiency of Vitamin B12, then it could lead to the accumulation of a compound called homocysteine

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described the elevated urinary excretion of digitalis-like factor under salt-loading conditions, underlining its involvement in regulation of hemostasis (Goto et al., 1989)

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