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However, NRF2 regulates a plethora of target genes involved in iron metabolism [ FTH1 , FTL , SLC40A1 (FPN), HMOX1 , ABCB6 , FECH , SLC48A1 , BLVRA/B , and HO-1 ], intermediate metabolism [ NROB2 (SHP), PPARG , AKR1C1-3 , G6PD , AKR1B1 , and ALDH1A1 ], and GSH metabolism ( GPX4 , SLC7A11 , GCLC/GCLM , GSS , GSTA1 , GSTP1 , PRDX1/6 , and TXNRD1 ) ( FIGURE 4 Another pathway that regulates GPX4 is the system X c -Gys-GSH redox axis

Premature ovarian failure in patients affected by systemic lupus erythematosus: a cross-sectional study

C., Chaumontet, J., Vande Voorde, R

Post-acne marks : Inflammation from pimples can leave behind stubborn brown or black spots

(PubMed) Tanaka S, Haruma K, Yoshihara M, et al

TLR4 is a transmembrane receptor that recognizes damage and pathogen-associated molecular patterns, functioning as a pattern recognition receptor 52