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scRNA experiment 48 male and 48 female C57BL/6 mice were obtained from Charles River Laboratories at 6 weeks of age

Practical Application Polyphenol-rich foods: Pomegranates, cranberries, grapes, green tea Omega-3 fatty acids: Fatty fish, walnuts, flaxseeds Prebiotic fibers: Chicory root, Jerusalem artichokes, garlic, onions Intermittent fasting: Research suggests fasting periods may increase Akkermansia populations Adequate sleep: Poor sleep quality correlates with reduced Akkermansia levels Exercise: Regular physical activity supports beneficial gut bacteria diversity What to Avoid: Excessive artificial sweeteners and emulsifiers in processed foods may negatively impact Akkermansia populations

For obesity (Wegovy): AOM rider on the plan, BMI 30 or BMI 27 with at least one qualifying comorbidity, documentation of lifestyle modification counseling, and clinical narrative from the prescriber

This helps you feel satisfied for longer and reduces hunger

doi: 10.1016/j.conb.2025.103021, 49

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