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It has been reported (118121) that ARS can inhibit the proliferation of chondrocytes and accelerate apoptosis and autophagy in RA rats, inhibit the migration and invasion of RA-FLSs and reduce the secretion of IL-1, IL-6 and IL-8, alleviate inflammatory symptoms and prevent the destruction of cartilage and bone, which is related to the inhibition of NF-kB signaling pathway, the activation of PI3K/AKT/mTOR signaling pathway, and the phosphorylation of p90 ribosomal kinase 2 (RSK2)

Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth

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doi: 10.1097/00007632-200104150-00007 [DOI] [PubMed] [Google Scholar]

Storage and handling requirements vary by compound class, format, and batch

Shigeki Kobayashi, et al