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Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin

Among these, riluzole (2-amino-6-trifluoromethoxy benzothiazole) is a neuroprotective drug approved for use in amyotrophic lateral sclerosis (Miller et al., 2002), which appears to act through decreasing glutamate release by stabilizing inactive Na + voltage-gated channels, shifting voltage dependence of the channel in the hyperpolarizing direction (Herbert et al., 1990)

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This marked it as the first dual GLP-1 and GIP receptor agonist for this purpose

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