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Hruby and Mac Hadley (University of Arizona, USA) in 19871989 Original development program Competitive Technologies Palatin Technologies , later spun off into PT-141 (bremelanotide) Target: non-selective agonist of MC1R, MC3R, MC4R, MC5R (more potent than -MSH, longer half-life) Standard experimental dose in human tanning studies: 0.025 mg/kg subcutaneously (Dorr 1996) In Dorr 1996 (n=10): increase in skin melanin density measured by colorimetry by ~25 % after a 10-day course Main adverse effects in the preclinical literature: nausea, flushing, hyperpigmentation (including atypical nevi), priapism Approximately 100+ publications in PubMed

Despite no broad alterations in cellular morphology, the changes in protein levels could still be part of the cellular response to oxidative stress [69, 70]

[PubMed] [Google Scholar] Martins R, Lithgow GJ, Link W

Humans express two genes encoding receptors for melatonin, MTNR1A and MTNR1B, encoding the MT 1 (initially called Mel1a) and MT 2 (initially called Mel1b) receptors, respectively