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Zonisamide is distributed to most tissues, but the drug is concentrated in the red blood cells

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10.1089/ham.2019.0083 37 FanC.SunR.NieM.WangM.YaoZ.FengQ.et al (2021)

If tolerated, the documented approach is to stay at the current step for the full interval before the next scheduled escalation not to leapfrog steps

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