Available at: Urva S, Coskun T, Loh MT, Du Y, Thomas MK, Gurbuz S, et al
Treatment-related malignant C-cell carcinomas occurred in 3% of females in the 3.0 mg/kg/day group
Key Nutrients Depleted by Corticosteroids Corticosteroids are associated with depletion of multiple nutrients essential for tissue repair, immune defense, and metabolic stability, including: Calcium, vitamin D, magnesium, potassium, zinc, selenium, vitamin C, and protein (1) Mechanisms of Steroid-Induced Nutrient Depletion Calcium & vitamin D: Reduced intestinal absorption and increased urinary loss osteopenia and fracture risk Zinc, selenium & vitamin C: Impaired immune function, delayed wound healing, increased infection risk Protein: Accelerated protein breakdown muscle wasting and connective tissue weakness Magnesium & potassium: Electrolyte imbalance fatigue, weakness, and cardiac rhythm disturbances Why Steroid-Induced Nutrient Depletion Impairs Healing By chronically elevating cortisol signaling, corticosteroids shift the body into a catabolic, stress-dominant state
The anterior pituitary becomes accustomed to amplified signaling, and when that signal vanishes, there's a lag period of 10-21 days before endogenous pulse patterns normalize
PlexusDx's Precision Peptide Genetic Test examines variants in peptide receptor pathways (GIPR, GLP1R, MC4R, FTO) that relate to overall metabolic and inflammatory predisposition
Serious side effects are rare but include acute pancreatitis (severe abdominal pain) and gallbladder issues
