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J Neurochem (2014) 128(3):45971

In addition, gut microbiota-derived metabolites, in particular the short-chain fatty acids (SCFA), acetic acid (acetate), propionic acid (propionate), and butyric acid (butyrate), as well as the bile acid metabolites, are significant contributors to the interconnections between the gut and the brain

[4] These milestones materially reduced legal and operational uncertainty for multinational trial sponsors, enabling CROs to standardize their DCT protocol templates, informed consent frameworks, and technology stack requirements across the principal commercial markets

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