Acute toxicity studies have failed to establish a lethal dose even at very high concentrations in rodents, a finding reported by the Sikiric group and referenced in several reviews
"Anything that can irritate or dry the skin has the potential to worsen KP," adds Dr
Urinary incontinence and sleep quality in older women with type 2 diabetes: a cross-sectional study
Whether self-administered or not is unclear, we contacted the authors for clarification
In addition, we used the following genetically engineered mouse strains from the Jackson Laboratory: Rosa26 mT/mG (RRID:IMSR_JAX:007676) 83 , Rosa26 M2rtTA /TetO-H2BGFP mice 84 , doubly transgenic for a reverse tetracycline-controlled transactivator (rtTA-M2) targeted to the Rosa26 locus and a HIST1H2BJ/EGFP fusion protein (H2BGFP) expressed from a tetracycline promoter element (RRID:IMSR_JAX:005104) 24,85 , multicolor reporter line Rosa26 tm1(CAG-Brainbow2.1)Cle ( R26-confetti , RRID:IMSR_JAX:017492) 86 Rosa26 flYFP/flYFP mice (R26-YFP, RRID:IMSR_JAX:006148) 87 , Rosa26 nT/nG (RRID:IMSR_JAX:023035), Nfe2l2 tm1Ywk (RRID:IMSR_JAX:017009), Rosa26 Cas9-P2A-EGFP (RRID:IMSR_JAX:024858) 63 , Notch1 fl/fl (RRID:IMSR_JAX:007181) 88 , LSL Kras +/ G12D (RRID:IMSR_JAX:019104) 83 and Rosa26 flDNM-GFP/wt (RRID:IMSR_JAX:032613 R26-DNM ) 60,89
Licht T, Keshet E (2015) The vascular niche in adult neurogenesis
