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References 1.Borbly A.A

Owen MR, Doran E, Halestrap AP (2000) Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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GLP-1 medications may be appropriate for adults who: Have a BMI of 30 or higher Have a BMI of 27 or higher with weight-related medical conditions Have struggled to lose weight through diet and exercise alone A medical consultation is required to determine if treatment is appropriate

This was a critical measure because one of the hypothesized effects of L-carnitine is enhanced fat oxidation, which can improve endurance performance