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Arizona gila monster, from whose venom exendin-4 was isolated, interacting with human GLP-1 receptors Exendin-4 became the basis for the creation of the first synthetic GLP-1 analogue, exenatide, which was approved in 2005 for the treatment of type 2 diabetes mellitus

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The cytosols of virtually all eukaryotic cells contain a SOD enzyme with copper and zinc (Cu-Zn-SOD)

[74] [62] [75] Selective alpha-1 blockers are similar in effectiveness but have slightly different side effect profiles

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One such molecule is the microglial cell surface receptor TREM2 (triggering receptor expressed on myeloid cells 2), which recognizes misfolded proteins like amyloid and activates microglia to clear them