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Together, these medications constitute a distinct and entirely new class of medications for type 2 diabetes called GLP-1 receptor agonists. Because the FDA wanted to be sure that these drugs help people to control their blood glucose levels without incurring risks that might worsen cardiovascular disease, the diabetes complication most likely to result in death, the agency ordered post-approval research of long-term outcomes in people taking them

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GLP-1R is expressed by various populations of central neurons, but it is still not fully clear which specific populations mediate the effects of GLP-1RAs

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