Be patient If you're just getting started on semaglutide, know that it can take time to reach maintenance doses and feel the full effects
The requirements include patients at high metabolic or cardiovascular risk with a BMI greater than 27 with prediabetes or established cardiovascular disease, or a BMI over 30 with uncontrolled hypertension despite treatment, advanced kidney disease, or heart failure
The mechanism involves inhibition of catechol-O-methyltransferase (COMT), which extends norepinephrine activity and slightly increases metabolic rate
Why does weight come back after stopping
Some patients notice appetite changes fairly quickly, while visible weight loss and body composition changes often take more time
This interaction may also help reduce leptin resistance, further promoting weight loss in females [58]