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Choosing Between Semaglutide and Tirzepatide for Microdosing From a pharmacology standpoint, semaglutide is a pure GLP-1 receptor agonist , while tirzepatide is a dual GIP/GLP-1 agonist that activates both GIP and GLP-1 receptors.[2,4] That dual mechanism likely contributes to tirzepatides strong weight-loss results at full doses compared with semaglutide in head-to-head and indirect comparisons.[2,7] In the context of microdosing: Some clinicians and patients feel that microdosing tirzepatide provides robust appetite control even at relatively low doses, though this is based largely on real-world experience rather than large trials
Behavioral Therapy: Behavioral therapy can be beneficial in addressing eating behaviors and lifestyle choices that contribute to obesity and poor diabetes control
After the discoveries of the gastrointestinal hormones, secretin in 1902 and gastrin in 1905, there was a time when diabetes was treated by injecting intestinal extract, assuming that gastrointestinal hormones were involved in glycemic control of the pancreas [2]
