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[10] Gastrointestinal disturbances-including nausea, loose stools, and a transient fishy body-odor attributable to trimethylamine production from excessive carnitine and choline metabolism-occur in a minority of recipients and are usually self-limiting within 24 to 48 hours after injection

OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship

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[357] As discussed in the CY 2026 OPPS/ASC proposed rule (90 FR 33771 and 33772), to provide flexibility for REHs, we proposed that REHs could elect to report either the Emergency Care Access & Timeliness eCQM or the Median Time for Discharged ED Patients measure beginning with the CY 2027 reporting period/CY 2029 program determination

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## **What is a vitamin B-12 injection?** HCPCS code J3420 refers to an injection of vitamin B-12 (cyanocobalamin), a synthetic form of the vitamin used to treat pernicious anemia, dietary folate deficiency, and other specified B-group deficiencies