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Hyperleptinemia In animals it has been observed that in those where defects in the leptin signaling pathway are present, either because they produce no functional hormone (ob/ob mice) [29] or because they express defective forms (fa/fa rats) or that do not express their receptor (db/db mice), are characterized by hyperphagia and massive early-onset obesity, in addition to diabetes, hypothermia and infertility

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