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In the biomarker discovery and validation set, the disease group consisted of a mixture of patients exposed and unexposed to drug treatment including antidepressants for the treatment of MDD

The most effective options include CoQ10, magnesium glycinate, vitamin B12, vitamin D, acetyl L-carnitine, omega-3 fatty acids, Rhodiola, and ashwagandha

Saxenda, 2014), semaglutide (Ozempic, 2017

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This mitochondrial injury promotes the release of apoptotic mediators like cytochrome c and caspases, initiating programmed cell death

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