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Bernardini, S

As you age, NAD+ levels decline, leading to reduced energy, cognitive decline, and increased susceptibility to age-related diseases

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But due to the high specific activity of citric acid cycle enzyme fumarase, tissue malate and fumarate levels are in near-equilibrium, and their levels are therefore most frequently altered proportionally (Krebs, 1953)

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Dickerhof N., Pearson J.F., Hoskin T.S., Berry L.J., Turner R., Sly P.D., Kettle A.J., Arest C.F

Theyre especially beneficial for women with MTHFR gene variants , where the ability to process folic acid from supplements is impaired