What we know from TRIUMPH-4 (blood pressure through 68 weeks): Systolic BP: -14.0 mmHg (12mg dose, efficacy estimand) Diastolic BP: -4.3 mmHg average reduction These reductions persisted even as weight loss plateaued in the final weeks, suggesting blood pressure benefits may be partially independent of weight possibly due to direct GLP-1 and glucagon receptor effects on vascular function
doi: Rachidi S, Sood AJ, Patel KG, Nguyen SA, Hamilton H, Neville BW, Day TA
What has not changed is the underlying evidence base
Now compare that to a note that only says, discussed weight loss. That second note is much harder to use
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En EM/SFC y covid persistente suele ser recomendable introducir cambios de forma gradual y evaluar tolerancia clnica, especialmente en presencia de empeoramiento post-esfuerzo (PEM)