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Noradrenergic hyperactivity has been shown to be an important component of the stress response and dysregulation of noradrenergic signaling has been implicated in the pathogenesis of anxiety and depression disorders

2 Likes Kelman January 31, 2026, 11:50pm #33 Beth: Just sharing that after using DSIP after almost a month, I see zero difference to my deep sleep (according to OURA) Most of my doses were 250mcg Absolutely ZERO effect for me either

Curcumin has been found to inhibit A fibril formation and extension and to destabilize preformed fibrils in vitro (51-53)

At 0.5%, you're still delivering concentrations far exceeding the nanomolar levels shown effective in research

Worth reading even if you've been tested in past and had a negative result

A randomized controlled trial of Warner and Arnspiger presented no significant improvement after 50,000 IU of vitamin D supplementation once per week for three months [49]