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Mitochondria contain 1015% of total GSH, and the concentration of GSH in mitochondria is similar to that of the cytoplasmic matrix [57, 58]

Kumar A, Vaiphei KK, Singh N, Datta Chigurupati SP, Paliwal SR, Paliwal R et al (2024) Nanomedicine for colon-targeted drug delivery, strategies focusing on inflammatory bowel disease and colon cancer

CDK12: cellular functions and therapeutic potential of versatile player in cancer

Glutathione has many important functions in the body including: Supporting DNA synthesis, helping to create and repair DNA (1) Breaking down free radicals - this is a big one

However, a subset of EVs can evade degradative pathways and enter recycling or transcytotic routes 157,163