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Archived from the original on 2012-10-11

Furthermore, a key limitation of oral administration is the off-target effect, where most of the drugs may act on peripheral organs before they can reach the CNS

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FAAX (Fentanyl Adulterated or Associated with Xylazine) was declared an emerging health threat by the US White House Office of National Drug Control Policy on April 12, 2023 (Gupta et al, 2023)