FIGURE 2 2.2.1 Increased endometrial glucose transporter protein 4 expression AMPK is a major energy receptor
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Cancer cells reprogram iron handling to sustain rapid proliferation, leading to expansion of the intracellular labile iron pool (LIP), composed largely of redox-active ferrous iron (Fe 2+ ) ( Fe 2+ + H 2 O 2 Fe 3+ + OH + OH - Hydroxyl radicals generated via this reaction initiate lipid peroxidation, particularly in membranes enriched with polyunsaturated fatty acids (PUFAs), thereby compromising membrane integrity and cellular viability ( - ) cystine/glutamate antiporter ( Figure 4 ) ( Figure 4 In parallel, an alternative ferroptosis defence pathway is mediated by ferroptosis suppressor protein 1 (FSP1), which operates independently of GPX4 by reducing coenzyme Q10 (CoQ10) to its active antioxidant form, ubiquinol
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