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Women using oral contraceptives should use a non-oral method or add a barrier method for 4 weeks after starting treatment and for 4 weeks after each dose increase

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Interestingly, the effects of metformin on HDACs are dissimilar because it increases the expression and/or activity of the class III HDAC SIRT1 (124127) and pharmacological doses of metformin in the cryopreservation media of mouse sperm in2duced SIRT1 activity (128)

Its among the new class of medications designed to assist with weight management