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Biotin (Vitamin B7): For Strong, Healthy Skin Why It Works One of the B vitamins, biotin, functions in the metabolism of fats and proteins and is critical for the synthesis of keratin, the main structural protein in hair, nails, and the outer surface of the skin

H.HullR.MortonD.PfisterR.RabemampianinaY.SmithD.et al (2001)

Gamma-Glu-Glu dose-dependently increased [Ca 2+ ] i with an EC50 value circa 300 M

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This results in the inhibition of phosphorylation activation of GLS, resulting in an inactive tetramer (Thangavelu et al., 2012