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This technique has the benefit of a relatively simple, gradual, and structured titration, which may improve confidence with and acceptance of an increasing need for multiple daily injections and may also reduce the incidence of hypoglycemia compared with going straight to basalbolus therapy [20]

In addition, substantia nigra dopaminergic neurons contain oxidant-generating enzymes, such as tyrosine hydroxylase and monoamine oxidase, as well as iron catalyzing the Fenton reaction producing superoxide and hydrogen peroxide radicals (9)

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