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Studies in animals have shown that high doses of GLP-1 drugs cause fetal problems, in part because the drugs reduce appetite so much

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However, in another study using an INS-1 832/3 cell line, the metformin-induced upregulation of GLP-1R mRNA expression was mediated via peroxisome proliferator-activated receptor- rather than AMPK pathway 30

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Some examples of these programs include housing and nutrition supports or infrastructure improvements to facilitate access for individuals transitioning from incarceration