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Upon neuronal activation, glutamate is released into the synaptic cleft, where it interacts with postsynaptic receptors, transmitting excitatory signals to neighboring neurons

in particular, it contributes to renal fibrosis through multiple signalling pathways, such as EMT, TGF-1 and oxidative stress, in CKD, and ERS inhibition can alleviate the progression of renal fibrosis 16,17,18,19

The idea is to get synergistic effects

This combination appeals to those pursuing comprehensive anti-aging strategies

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