Research suggested potential photoprotective benefits through increased eumelanin, though this has not been established as a therapeutic indication
However, in PD, reactive astrocytesparticularly pro-inflammatory A1 phenotypesactivate dopaminergic neuronal death via cytokine release, oxidative stress, and metabolic imbalance [250] (Fig
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Furthermore, HIIT has been demonstrated to trigger the acute release of plasma -endorphins, supporting both stress reduction and mood enhancement
If they persist beyond 4 weeks or worsen during dose escalation, contact your PlexusDx provider to discuss slower titration, hydration strategies, or alternative delivery methods