Cell 179, 11291143
In patients with type 2 diabetes, sitagliptin (100 mg/day) therapy significantly reduced the plasma levels of C-reactive protein (CRP), IL-6, IL-18, secreted phospholipase-A2, soluble intracellular adhesion molecule- (ICAM-) 1, and E-selectin compared with placebo
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Conversely, in [ 68 Ga]DOTATOC PET/CT, four of the six insulin-positive tumors (66.7%) were detected, whereas all the three insulin-negative tumors (100%) were visualized
Although direct fertility data remain limited, small studies in women with PCOS suggest improved menstrual regularity and ovulation rates
Other Side Effects: (which may be due to decreased osteoblast formation)