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Long-term safety in humans remains undefined due to absence of extended follow-up studies

While they may deliver noticeable results, it is essential to approach them with realistic expectations and professional guidance

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Aftercare Good aftercare (ongoing counseling, recovery coaching, peer support, relapse-prevention planning) helps make recovery long-term

Research consistently documents appetite stimulation as the most prominent and reproducible effect, followed by transient cortisol and prolactin co-secretion, water retention related to GH elevation, mild flushing or dizziness shortly after administration, and potential glucose metabolism effects in metabolically compromised research models

Studies in experimental animals have probed neural markers of these discrete reward processes, and these can be compared with imaging studies of anhedonic humans