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Each of these trials had different study populations, followed different methodological designs, and differed in relation to the primary endpoint

Retatrutide has produced the largest weight loss reported in any Phase 3 obesity trial so far, but a UK launch is at least 18 months away

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Dosing process: Similar to semaglutide, tirzepatide starts with a low initial dose that is slowly increased over time

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff