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They achieve this by the same mechanism: stimulating the release of insulin and suppressing the release of glucagon

The effect is typically modest and works best combined with sensible diet and regular activity

The proposal targets specific FDA-approved medications that help people lose weight safely

This effect is also observed after specific activation of GLP-1R in the NAc and most likely those receptors located on medium spiny neurons that express the dopamine-D1 receptors or dopamine-D2 receptors (Zhang et al., 2020)

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Both approaches demonstrate weight loss approaching the efficacy of bariatric surgery, but through different complementary receptor mechanisms