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The proponents of coffee enema use believe that the cafestol palmitate in coffee increases the activity of glutathione S-transferase, an enzyme that cause dilatation of bile ducts and excretion of bile through the colon wall, and that the coffee fluid stimulates peristalsis and drainage of bile from the gut [9,10,13]

However, suppression of ncBAF did not affect the SLC7A11 expression

Key finding: AOD 9604 reduced serum leptin by 56%, improved hypothalamic STAT3 phosphorylation, and restored leptin-induced POMC expression

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Oral glutathione supplements may have limited absorption

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