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Mazdutide is a separate GLP-1/glucagon dual agonist built on a different (GLP-1/glucagon oxyntomodulin-like) scaffold, and retatrutide extends the idea to three receptors by adding GIP-receptor agonism

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43 The focus should be on finding a starting point that feels achievable and building from there

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This decrease in muscle mass can account for as much as 38% of the total weight loss experienced by people on these drugs