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(Comprehensive review detailing the inter-related roles of B-complex vitamins in cellular metabolism, energy production, and neurological function)
Before receiving folic acid or methylcobalamin, patients should be assessed for deficiency and appropriate therapy started concurrently
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They disagreed
Monitoring and Follow-Up Regular monitoring of B12 levels through blood tests is essential to ensure that the treatment is effective and that B12 levels are maintained within the normal range
However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)
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