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Geriatric Patients: The pharmacokinetics of lamotrigine following a single 150-mg dose of lamotrigine were evaluated in 12 elderly volunteers between the ages of 65 and 76 years (mean creatinine clearance = 61 mL/min, range: 33 to 108 mL/min)

However, your healthcare professional may switch you from metformin to another anti-diabetic drug for various reasons, such as if metformin is not controlling blood glucose levels, you have severe side effects, or there are drug interactions between metformin and your other medicines

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Grillo MP, Tadano Lohr M, Wait JC

Nowson CA, OConnell SL, et al

Because zinc deficiency can cause poor inflammation control and increased allergic reactivity, this suggests there may be a vicious cycle involving zinc depletion and allergy/inflammation