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While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3

[PubMed] Kamdi, S

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The PreissHandler pathway can take place in several tissues, such as the brain, heart, kidney, small intestine, and liver, as shown by the expression of NAPRT and NADS 11

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