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Results from observational, target trial emulation, Mendelian randomization, and preliminary controlled studies have reported benefits with GLP-1 RAs across multiple clinical targets including alcohol-,substance- and tobacco-use disorders, mood and psychotic disorders, binge-eating disorder, and major neurocognitive disorders

The ERK1/2 pathway is a major signaling cascade involved in cell growth, proliferation, and differentiation, including processes vital for angiogenesis