This beneficial effect was maintained up to Day 43 following the single administration of the two highest doses

Key TakeawaysGLP-1 medications may increase the risk of low blood pressure eventsOlder adults and people with type 2 diabetes seem to be most vulnerablePatients already taking blood pressure medication should be closely monitored by their doctor.MONDAY, June 15, 2026 (HealthDay News) Researchers are flagging a potential safety concern tied to GLP-1 medications and blood pressure.A new Northwestern Medicine study tracked more than 42,000 adults who started semaglutide, tirzepatide or liraglutide while taking multiple blood pressure drugs.The authors tracked hypotensive episodes, including dizziness, fainting, falls, low blood pressure diagnoses and very low blood pressure readings.The overall rate of these events jumped from 8.7% to 10.2% within six months of starting GLP-1 therapy, and remained significant at 12 months, the study found.The risk was highest in adults 65 and older and people with type 2 diabetes.Researchers also found the increase could not be explained by weight loss alone."I'm a big proponent of GLP-1s, they are huge

Why Tirzepatide Causes Gastrointestinal Effects Tirzepatide activates two receptor systems simultaneously: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)
Semaglutide Semaglutide, originally developed for managing blood sugar levels in people with diabetes, is now an FDA-approved weight loss solution
Factors such as age, hormonal balance, and prior experience with peptide therapies should also be factored in, ensuring that the selected peptide aligns with the unique contours of ones physiological landscape and fitness goals
Cytokine Modulation Pro-inflammatory cytokines like TNF-alpha, IL-6, and IL-1beta drive the inflammatory cascade that causes pain, swelling, and tissue damage