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3.7 Summary of metabolic outcomes: building foundation for fertility treatment Across available trials, GLP-1RAs consistently improve metabolic drivers that are clinically relevant to fertility planning in PCOS

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Combined with above-mentioned data, GLP-1RAs show a positive impact on the suppression of NLRP3 inflammasome (Figure 2)

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DCM can lead to cardiac systolic or diastolic dysfunction, further causing heart failure with reduced ejection fraction and heart failure with normal ejection fraction, seriously affecting the patients quality of life