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4) Underexplored therapeutic strategies and model limitations: Preclinical studies have relied heavily on lupus-prone mouse models (e.g., MRL/lpr mice), which may not fully recapitulate human LNs complexity (e.g., genetic heterogeneity, variable disease progression, and response to therapy)

The investigators reported improvements in skin density, dermal thickness, laxity (firmness), and reduction of fine lines in the GHK-Cu arm compared with vehicle control over the 12-week treatment period [3]

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It does not cause hand tremors, heart palpitations, or sleep problems, so it can be used at any time of the day

The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes

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