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Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy
Finn, MD, section chief of Obesity Medicine at the Dartmouth Health Walter and Carole Young Center for Digestive Health
Clinical trials show Contrave produces modest weight loss (510% body weight in responders over 56 weeks), with effects primarily through central nervous system modulation rather than slowed gastric emptying or incretin hormone stimulation
And over half stop within the first three months, which might be enough to achieve some mostly cosmetic weight loss, but little more
(Source: Drugs.com, May 2026) A related risk worth naming: Nausea during titration can cause patients to under-eat protein specifically, which compounds lean mass loss
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