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Although Compounds 1.62 and 1.64 lost activity for the GPx and/or GR enzymes responsible for the antioxidative effect and regeneration of the thiol group of GSH using other reductant sources, respectively, these compounds were still able to rescue the cell death of UVA irradiated cells as the neutralisation the free radicals produced by UVA irradiation could be achieved by other pathways
The authors concluded that deacetylation occurs rapidly and completely before or immediately upon entry into systemic circulation indicating that the full administered dose is converted to GSH prior to reaching the bloodstream
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A.Maia-DantasA.et al (2016)
