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On average, people lose 15% of their body weight on GLP-1s

The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them

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With its dual mechanism of action, Semaglutide GLP-1 enables significant weight reduction, with some individuals experiencing a loss of 15% or more of their initial body weight over a year

Tirzepatide adds a second hormone target (GIP), which is part of why it showed larger average weight loss in trials

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