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Obesity Reviews (2004) 7

they exist to make the published numbers legible

supports cellular function and detoxifies the body

2025;3:1008132 DOI: Received: September 03, 2025 Accepted: September 23, 2025 Published: October 30, 2025 Academic Editor: Alessandra Tolomelli, University of Bologna, Italy The article belongs to the special issue Innovative Therapeutics in Hepato-Gastroenterology Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading cause of cirrhosis, hepatocellular carcinoma, and liver-related mortality worldwide

The available human data suggests significant regression toward baseline after discontinuation, which raises mechanistic questions about whether the compounds produce structural metabolic change or ongoing pharmacological modulation

Vaspin binding to the LRP1 requires initial contact to cell-surface glycosaminoglycans and a non-heparin-binding vaspin variant does not internalize in LRP1 expressing adipocytes 26